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Search Results for " A549 cells "

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145

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T2430	HPOB		Apoptosis , HDAC
			Apoptosis , HDAC
T9891	PARP1-IN-8	N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide	PARP
	PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).		PARP
T1083L	Theophylline monohydrate	Quibron	HDAC , PDE , Adenosine Receptor
	Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ...		HDAC , PDE , Adenosine Receptor
T12344L1	OTS186935 FA	OTS186935 FA（2093400-18-9 Free base）	Histone Methyltransferase
	OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.		Histone Methyltransferase
T8979	AEM1		Nrf2
	AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibit...		Nrf2
T62281	PARP-1-IN-2		PARP
	PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel...		PARP
T8967	SW155246		DNA Methyltransferase
	SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM). SW155246 induces re-expression of the tumor suppressor geneRASSF1 in A549 cells.		DNA Methyltransferase
T15451	GW-870086		Glucocorticoid Receptor
	GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB).		Glucocorticoid Receptor
T7018	WZB117		transporter
	WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.		transporter
T22396	PF-6274484	PF 6274484	EGFR
	PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and ...		EGFR
T36316	MTOR inhibitor-8	mTOR-IN-8	mTOR , Autophagy
	mTOR inhibitor-8 is a potent mTOR inhibitor and autophagy inducer with antiviral and antitumor activity. mTOR inhibitor-8 inhibits the growth of A549 cells, which can be used to study non-small cell lung cancer.		mTOR , Autophagy
T1887	Inauhzin	INZ	Sirtuin
	Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...		Sirtuin
T22317	DRB18		transporter
	DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associate...		transporter
T60654	KDM4C-IN-1		Histone Demethylase
	KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia.		Histone Demethylase
T8816	NAE-IN-M22	NEDD8 inhibitor M22	Apoptosis , E1/E2/E3 Enzyme
	NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can i...		Apoptosis , E1/E2/E3 Enzyme
T7082	HDAC8-IN-1		HDAC
	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ...		HDAC
T63343	ULK1-IN-2		Apoptosis , Autophagy
	ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells....		Apoptosis , Autophagy
T15411	GPNA hydrochloride		Apoptosis , Others
	GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT)....		Apoptosis , Others
T9105	NF-κB-IN-1	1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-	IκB/IKK , NF-κB
	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir...		IκB/IKK , NF-κB
T78156	MC4033		Apoptosis
	MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1]. Additionally, treatment with MC4033 at concentrations of 25, 50, 100, and 200 µM f...		Apoptosis
T36493	CMLD-2		Apoptosis , HuR
	CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor ef...		Apoptosis , HuR
T20882	4-Nitrobenzoic acid	Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid
	4-Nitrobenzoic acid (4Nitrobenzoic acid) is a pharmaceutical intermediate often found in the production of folic acid, DABA, PABA and dyes.
T9582	CLEFMA		NF-κB
	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.		NF-κB
T19661	8-Chloroadenosine	NSC 354258,8-Cl-Ado,NSC354258,NSC-354258	AMPK
	8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch...		AMPK
T11421	Glutaminase-IN-1	CB839 derivative	transporter
			transporter
T35610	2,5-dimethyl Celecoxib		Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
	2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ...		Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK
T11929	M2N12		Phosphatase
	M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of  0.53  μM and 1.39 μM. Anti-tumor activity. M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhi...		Phosphatase
T72784	OTUB1/USP8-IN-1		DUB
	OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung c...		DUB
T78941	Anticancer agent 130		Apoptosis
	Anticancer agent 130 (compound 8d) significantly induces apoptosis in A549 cells [1].		Apoptosis
T74400	TC113
	TC113, a Gemcitabine (GEM)-based conjugate incorporating the c(RGDyK) sequence, is internalized by A549 cells via the integrin αvβ3 pathway. It demonstrates significant antiproliferative effects on both WM266.4 and A549 ...
T63590	C-Met-IN-10
	c-Met-IN-10 is a potent c-Met kinase inhibitor (IC50: 16 nM). c-Met-IN-10 inhibits the activity of cancer cells A549, H460 and HT-29, and inhibits A549 cell movement by inhibiting HT-29 cell colony formation, which in tu...
T31411	DHA-37	DHA 37
	DHA-37 is an inducer of autophagic cell death through upregulation of HMGB1 in A549 cells.
T82715	Cisplatin-resistant cells-IN-1
	Cisplatin-resistant cells-IN-1 (Compound 8) exhibits high cytotoxicity against Cisplatin-resistant cells and effectively diminishes metabolic activity at low nanomolar concentrations, with an IC50 ranging from 0.14 to 1....
T61405	LSD1-IN-14
	LSD1-IN-14, a powerful and specific inhibitor of LSD1 (with an IC50 value of 0.89 μM), effectively suppresses the growth of A549 and THP-1 cells and promotes the apoptosis of tumor cells [1].
T72544	4-Formylcolchicine
	4-Formylcolchicine, a potent anticancer agent, demonstrates cytotoxicity with IC 50 values of 1.007 µM for A549 cells, 0.128 µM for HT-29 cells, and 0.054 µM for HCT116 cells.
T74605	Antitumor agent-64
	Antitumor Agent-64 (Compound 8d), a diosgenin derivative, exhibits potent cytotoxic activity against the A549 cell line and induces apoptosis in A549 cells through the mitochondria-related pathway [1].
T83914	Glutaminase C Inhibitor 11
	Glutaminase C Inhibitor 11 is a potent inhibitor specifically targeting Glutaminase C (GAC), demonstrating significant inhibition of GAC enzyme activity with an EC50 value of 10.64 nM. It effectively diminishes the viabi...
T36197	CAY10747
	CAY10747 is an inhibitor of the protein-protein interaction between heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) and a derivative of celastrol .1It decreases protein levels of the Hsp90-Cdc37 complex ...
T72407	C-Met/MEK1/Flt-3-IN-1
	Antiproliferative Against-3 (comp 33) demonstrates significant activity against Hela (IC 50 = 0.21 µM), A549 (IC 50 = 0.39 µM), and MCF-7 (IC 50 = 0.33 µM) cell lines. Additionally, it induces apoptosis in a dose-depende...
T64179	Anticancer agent 65
	Anticancer agent 65 showed good results in tumour cell lines, especially A549 cells (IC50: 1.07 μM). anticancer agent 65 blocked the cell cycle of A549 cells in S phase, induced apoptosis, increased the expression of p53...
T81569	PAK4-IN-3		PAK
	PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM. It also induces concentration-dependent apoptosis in A549 cells an...		PAK
T68738	(±)-γ-Tocopherol
	(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the syn...
T60546	Anti-MRSA agent 6
	Anti-MRSA agent 6 (compound 3q6) is a potent anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) agent with low cytoxicity for MCF-7, A549 cells [1].
T78813	CDK2/Bcl2-IN-1		CDK
	CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibits Bcl-2 and promotes apoptosis in A549 lung cancer cells [...		CDK
T82000	JV-1-36
	JV-1-36, a growth hormone-releasing hormone (GHRH) antagonist, suppresses reactive oxygen species production in A549 lung cancer cells and serves as a research tool to investigate GHRH antagonists' effects in vitro [1].
T68209	Kopsoffinol
	Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine...
T73515	MC2590		Apoptosis , HDAC
	MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.		Apoptosis , HDAC
T81394	PRO-HD1		HDAC
	PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50 of 5.8 µM [1].		HDAC
T72476	Anticancer agent 59
	Anticancer agent 59, an inhibitor active against various cancer cell lines, particularly demonstrates efficacy in A549 cells with an IC 50 value of 0.2 μM. It prompts apoptosis, elevates Ca2+ and ROS levels within cancer...

Compounds

HPOB

T2430

Synonym:

Target: Apoptosis, HDAC

PARP1-IN-8

T9891

Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide

Target: PARP

Theophylline monohydrate

T1083L

Synonym: Quibron

Target: HDAC, PDE, Adenosine Receptor

OTS186935 FA

T12344L1

Synonym: OTS186935 FA（2093400-18-9 Free base）

Target: Histone Methyltransferase

Target: DNA Methyltransferase

GW-870086

T15451

Synonym:

Target: Glucocorticoid Receptor

Target: mTOR, Autophagy

Target: Histone Demethylase

NAE-IN-M22

T8816

Synonym: NEDD8 inhibitor M22

Target: Apoptosis, E1/E2/E3 Enzyme

Target: Apoptosis, Autophagy

GPNA hydrochloride

T15411

Synonym:

Target: Apoptosis, Others

NF-κB-IN-1

T9105

Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Target: IκB/IKK, NF-κB

Target: Apoptosis, HuR

4-Nitrobenzoic acid

T20882

Synonym: Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258

Target: AMPK

Glutaminase-IN-1

T11421

Synonym: CB839 derivative

Target: transporter

2,5-dimethyl Celecoxib

T35610

Synonym:

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cisplatin-resistant cells-IN-1

Glutaminase C Inhibitor 11

c-Met/MEK1/Flt-3-IN-1

Target: Apoptosis, HDAC

カタログ番号	製品名	別名	ターゲット
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T3008	Lawsone methyl ether	2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone	Apoptosis , Antibacterial , Antifungal
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...		Apoptosis , Antibacterial , Antifungal
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T2S1593	Gypenoside XLVI		Others
	Gypenoside XLVI shows strong cytotoxic activity against A549 cells, with the IC50 values of 52.63±8.31 ug/ml.		Others
T4S1540	Myrislignan		Apoptosis , NF-κB
	Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induc...		Apoptosis , NF-κB
T3771	Methyl protodioscin	Smilax saponin B,NSC-698790	Apoptosis
	Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...		Apoptosis
TN2554	1-Monopalmitin	Glyceryl palmitate	Apoptosis
	1-Monopalmitin (Glyceryl palmitate) is a small molecule compound extracted from Mougeotia nummuloides and Spirulina major with potential antitumor activity, inhibiting proliferation of A549 and SPC-A1 cells, and inducing...		Apoptosis
T6S0077	Byakangelicol		COX
	1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...		COX
T3404	Cucurbitacin B	Cuc B,DATISCACIN,Amarine	Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
T3870	Cyasterone	Cyasteron	Apoptosis , EGFR
	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.		Apoptosis , EGFR
TN1721	Gypenoside L		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
	Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a...		ERK , p38 MAPK , Calcium Channel , NF-κB , ROS
T2S0618	β-Elemonic Acid	3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid	Apoptosis , Reactive Oxygen Species , COX
	β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are rel...		Apoptosis , Reactive Oxygen Species , COX
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
TN1003	DL-Alanine	DL-2-Aminopropionic acid	Endogenous Metabolite
	DL-Alanine (DL-2-Aminopropionic acid) is an amino acid that is a racemic compound of L- and D-alanine.DL-Alanine is often used as a reducing and capping agent in conjunction with aqueous silver nitrate for nanoparticle g...		Endogenous Metabolite
TN1516	Cnidicin		NOS , NO Synthase
	Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the pr...		NOS , NO Synthase
T2973	Astragaloside IV	AST-IV,AS-IV	MMP , ERK , Estrogen/progestogen Receptor , JNK
	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...		MMP , ERK , Estrogen/progestogen Receptor , JNK
TN5538	6-Methoxykaempferol		Others
	6-Methoxykaempferol is a flavonoid found in brazilian propolis. 6-Methoxykaempferol has anti-proliferative activity against cancer cells, neuroprotective effects on isolated rat brain synaptosomes and reduces glutathione...		Others
TN5274	Yunnancoronarin A		Others
	Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.		Others
TN2666	1alpha-Hydroxytorilin		Others
	1alpha-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.		Others
TN5373	Ustusolate A
	1. Ustusolate A shows weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.
TN2114	Pseudoginsenoside Rh2		ERK , Raf , p53
	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenosid...		ERK , Raf , p53
T82429	Euphoheliosnoid A
	Euphoheliosnoid A (Compound 24), a diterpenoid, significantly enhances natural killer (NK) cell-mediated cytotoxicity against H1299-luci cells and A549-luci cells at a concentration of 2.5 μM [1].
T82427	Euphoscopin C
	Euphoscopin C, a diterpenoid isolated from Euphorbia helioscopia, significantly enhances the cytotoxic activity of natural killer (NK) cells against H1299-luci and A549-luci cells [1].
TN3617	Cedrelopsin		Others
	Cedrelopsin shows significant inhibition against A549 cells with IC50 values of 3.6-5.9 ug/mL.		Others
T13629	Cyclo(Ala-Gly)		Others
	Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.		Others
TN3429	Aphagranin A		Others
	Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.		Others
T83481	1,1′-Disinomenine
	1,1′-Disinomenine, an alkaloid extracted from the stems of Sinomenium acutum, exhibits modest inhibitory activity against A549 and Hela cells [1].
TN2669	1beta-Hydroxytorilin		Others
	1beta-Hydroxytorilin exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.		Others
TN5211	Ustusolate E		Others
	Ustusolate E exhibits moderate cytotoxicity against A549 and HL-60 cells with the IC50 value of 9.0 microM.		Others
T21523	β-Tocotrienol	Beta-Tocotrienol	Caspase
	Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations.		Caspase
TN5879	Edgeworin
	Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A...
TN1872	Linderone		Others
	Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.		Others
TN4356	Jolkinolide A		Akt , STAT , mTOR
	Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs.		Akt , STAT , mTOR
TN2191	Scutebarbatine A		BCL , Caspase
	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and...		BCL , Caspase
TN5210	Ustusolate C		Others
	Ustusolate C and ustusolate E exhibit moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively.		Others
T83104	Anthragallol 1,2-dimethyl ether
	Anthragallol 1,2-dimethyl ether (compound 11), isolated from O. umbellata, exhibits cytotoxicity against A549 and MDA-MB-231 cells, with IC50 values of 5.9 μg/ml and 8.8 μg/ml, respectively [1].
T82808	Bufoserotonin C
	Bufoserotonin C, an indole alkaloid derived from the traditional Chinese medicine Chansu, exhibits antitumor activity and demonstrates an IC50 value of 34.3 μM in A549 cells [1] [2].
TN4172	Guajadial B		Topoisomerase
	Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM to...		Topoisomerase
T81132	Soladulcoside A
	Soladulcoside A, a steroidal glycoside with antineoplastic properties, is derived from the entire Solanum nigrum plant. It demonstrates inhibitory effects on A549 cells, suggesting its applicability in researching non-sm...
T37543	Anhydroepiophiobolin A
	Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, an...
T82298	Glucozaluzanin C
	Glucozaluzanin C, a lignan extracted from the MeOH extract of Ainsliaea acerifolia (Compositae) roots, demonstrates ED50 values of 2.45 μg/mL for A549 cells, 1.37 μg/mL for SK-OV-3 cells, 0.40 μg/mL for SK-MEL-2 cells, 1...
T75646	Moroidin
	Moroidin, a bicyclic octapeptide from the Urticaceae-type cyclopeptide family, acts as a tubulin polymerization inhibitor, demonstrating significant effects on purified tubulin polymerization. It exhibits cytotoxicity ag...
TN3771	Dasycarpol		Others
	Dasycarpol(9beta-Hydroxyfraxinellone) shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM. Dasycarpol also shows m...		Others
TN4959	Schizandriside		Prostaglandin Receptor
	Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells. It shows significant cyt...		Prostaglandin Receptor
T8199	(±)-α-Bisabolol	Bisabolol	Apoptosis , Antioxidant
	(±)-α-Bisabolol (Bisabolol) isa sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating, anti-inflammatory, antioxidant and anticancer ...		Apoptosis , Antioxidant
T83323	4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside
	4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside (compound 3), a natural anticancer agent extracted from Lilium regale, exhibits potent inhibitory effects on the proliferation of A54...
T83597	(+)-Menthyl acetate
	(+)-Menthyl acetate, extracted from the essential oil of Cunila angustifolia Benth, exhibits selective cytotoxicity, demonstrating higher efficacy against the MCF-7 cell line with an IC50 of 34.0 μg/mL and lower efficacy...
TN3525	Boehmenan		ERK , Phosphatase , EGFR , PARP , MEK , Wnt/beta-catenin , Akt , Caspase , STAT , p53
	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotox...
T35750	Trypacidin
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, re...
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天然物製品

Theophylline

T1083

Synonym: Theo-24,1,3-Dimethylxanthine

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Matrine

T2870

Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Lawsone methyl ether

T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone

Target: Apoptosis, Antibacterial, Antifungal

sphondin

T5758

Synonym:

Target: COX, Prostaglandin Receptor

Target: Apoptosis, NF-κB

Methyl protodioscin

T3771

Synonym: Smilax saponin B,NSC-698790

Target: Apoptosis

1-Monopalmitin

TN2554

Synonym: Glyceryl palmitate

Synonym: Cuc B,DATISCACIN,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Cyasterone

T3870

Synonym: Cyasteron

Target: Apoptosis, EGFR

Gypenoside L

TN1721

Synonym:

Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS

β-Elemonic Acid

T2S0618

Synonym: 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid

Target: Apoptosis, Reactive Oxygen Species, COX

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Target: Others

DL-Alanine

TN1003

Synonym: DL-2-Aminopropionic acid

Target: Endogenous Metabolite

Cnidicin

TN1516

Synonym:

Target: NOS, NO Synthase

Astragaloside IV

T2973

Synonym: AST-IV,AS-IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

1alpha-Hydroxytorilin

Pseudoginsenoside Rh2

TN2114

Synonym:

Target: ERK, Raf, p53

Synonym: Beta-Tocotrienol

Target: Akt, STAT, mTOR

Anthragallol 1,2-dimethyl ether

Target: Topoisomerase

Anhydroepiophiobolin A

Target: Prostaglandin Receptor

(±)-α-Bisabolol

T8199

Synonym: Bisabolol

Target: Apoptosis, Antioxidant

4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside

Target: ERK, Phosphatase, EGFR, PARP, MEK, Wnt/beta-catenin, Akt, Caspase, STAT, p53

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi)	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPK-00306	TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated	Human	HEK293 Cells
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...

TGFBR1 Protein, Human, Recombinant (mFc & Avi)

TMPK-00305

Species: Human

Expression System: HEK293 Cells

TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated

TMPK-00306

Species: Human

Expression System: HEK293 Cells